History of Generic Viagra (Sildenafil)

The history of Sildenafil is one of confusion and uncertainty about the true purpose of the drug’s use. Sildenafil today is available as one of the best known drugs to combat Erectile Dysfunction (ED) in men. It is marketed under the brand names of Viagra, and is also available under the brand Revatio. While ED is the primary Sildenafil focus, the drug is also prescribed for other conditions, such as Pulmonary Arterial Hypertension (PHA).

Uncertain beginnings!

pfizer-sildenaf-300x200But Sildenafil didn’t start out to be the wonder “little Blue Pill” for ED that it (Viagra) is well known as today. In fact, the British scientists who were instrumental in researching Sildenafil had no clue what it could do for men’s erectile problems. They were looking for a cure for heart diseases, and that’s what all of their experimentation was directed towards.

Sildenafil was patented in 1991 as “heart medication”, and so began its rather uncertain history. The early 1990’s saw countless experiments and trials by Pfizer trying to confirm that the drug could actually provide a breakthrough in coronary disease treatments. Sadly though, none of the trials proved conclusive enough to confirm that Sildenafil could in fact be a cure for heart ailments.

So now what? Should the millions of dollars spent until now be flushed? Should the company abandon its trials and start afresh? The future for Sildenafil looked bleak – at least as far as its capabilities as a heart condition remedy was concerned!

Unexpected breakthrough!

sildenaf-factoryWhile Pfizer was still doing its trials of Sildenafil, other agencies were busy conducting unrelated experiments which provided scientists a better understanding of how the erectile mechanism of the male sex organ worked. The findings revealed startling insight into how blood flow (or the lack thereof) to the penile region caused erections to happen, and also stifle them.

These conclusions were remarkable indeed! In view of the new evidence on the erection process, scientists at Pfizer reviewed their own findings through the Sildenafil trials. They noticed that many of their male test subjects reported having “unexpected erections” when they were on the medication. Could there be something in this?

As a result of this unexpected breakthrough, further trials were then conducted, and new patents were filed for Sildenafil as a phosphodiesterase sort 5 inhibitor (or PDE5 inhibitor). As a result, the “Little Blue Pill” finally received US Federal Drug Administration (FDA) approval in 1998 – and the rest is indeed history! In 2012 alone, over 8 million prescriptions were written for Viagra (Sildenafil) alone, and it has established itself as the top ranked ED pill globally!